Symbol
Name
ID

Stat3
signal transducer and activator of transcription 3
MGI:103038

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Eosinophilia	Superficial thrombophlebitis	Lymphoma	Elevated erythrocyte sedimentation rate
Disease(s) Associated with STAT3	Increased circulating IgE level	Eosinophilia	Superficial thrombophlebitis	Lymphoma	Elevated erythrocyte sedimentation rate
Behcet's disease
hyper IgE recurrent infection syndrome 1
rheumatoid arthritis

Mouse Phenotypes

increased thymocyte apoptosis

increased T cell apoptosis

decreased T cell proliferation

decreased thymocyte number

abnormal CD4-positive T cell differentiation

abnormal T-helper 17 cell differentiation

increased neutrophil cell number

increased granulocyte number

increased dendritic cell number

increased T-helper 1 cell number

decreased T-helper 17 cell number

increased T-helper 17 cell number

increased CD4-positive, alpha-beta T cell number

increased regulatory T cell number

increased T cell number

increased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

increased IgE level

decreased IgG1 level

decreased IgG3 level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal macrophage physiology

Availability

Mouse Genotype

Stat3^tm3Vpo/Stat3^tm3Vpo

Stat3^tm1Dnl/Stat3^tm1Dlv

Tg(Stat3*)9199Alau/0

Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}
Tg(Cd4-cre)1Cwi/0 (conditional)

Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv}/Gt(ROSA)26Sor^{tm1(Stat3*A661C*N663C)Sbkv} (conditional)

Stat3^tm1Dlv/Stat3^tm1Dlv
Tg(Cd4-cre)1Cwi/? (conditional)

Stat3^tm1Dlv/Stat3^tm1Dlv
Tg(Csf1r-icre)1Jwp/0 (conditional)

Stat3^tm1Dlv/Stat3^tm1Dlv
Tg(MMTV-cre)4Mam/0 (conditional)

Stat3^tm1Flv/Stat3^tm1Flv
Tg(Tek-cre)12Flv/0 (conditional)

Stat3^tm1Vpo/Stat3^tm1Vpo
Tg(Mx1-cre)1Cgn/0 (conditional)

Stat3^tm2Aki/Stat3^tm2Aki
Tg(Lck-cre)1Jtak/0 (conditional)

Stat3^tm2Aki/Stat3^tm2Aki
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Stat3^tm1Vpo/Stat3^tm2Vpo
Tg(Mx1-cre)1Cgn/0 (conditional)

Stat3^tm1Xyfu/Stat3^tm1.1Xyfu
Tg(Ttr-cre)10-3Xyfu/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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